GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7045881 | 1 | rs7045881 | chr9:26935996 | IFT74 | chr9:26947037-27062923:+ | 0.24 | 4.56 | 6.56E-6 | Schizophrenia |
| THCA | cis | rs7045881 | 1 | rs7045881 | chr9:26935996 | LRRC19 | chr9:26993143-27005691:- | -0.74 | -9.99 | 1.77E-21 | Schizophrenia |
| THCA | cis | rs2209875 | 1 | rs7046217 | chr9:91780877 | CKS2 | chr9:91926113-91931617:+ | -0.25 | -4.44 | 1.13E-5 | Pelvic organ prolapse (moderate/severe) |
| THCA | cis | rs2209875 | 1 | rs7047644 | chr9:91826500 | CKS2 | chr9:91926113-91931617:+ | -0.24 | -4.57 | 6.12E-6 | Pelvic organ prolapse (moderate/severe) |
| THCA | cis | rs877636 | 1 | rs705696 | chr12:56480648 | RAB5B | chr12:56367760-56388478:+ | 0.25 | 4.36 | 1.57E-5 | Cognitive function |
| THCA | cis | rs877636 | 1 | rs705696 | chr12:56480648 | RPS26 | chr12:56435686-56438005:+ | 0.7 | 12.79 | 2.08E-32 | Cognitive function |
| THCA | cis | rs7061710 | 1 | rs7061710 | chr1:171080615 | FMO3 | chr1:171060018-171086957:+ | -0.29 | -4.81 | 2.05E-6 | Blood metabolite levels |
| THCA | cis | rs4732038 | 1 | rs706201 | chr7:134251041 | AKR1B1 | chr7:134127107-134143888:- | -0.23 | -4.89 | 1.4E-6 | Longevity |
| THCA | cis | rs4732038 | 1 | rs706202 | chr7:134250704 | AKR1B1 | chr7:134127107-134143888:- | -0.21 | -4.45 | 1.06E-5 | Longevity |
| THCA | cis | rs7069346 | 1 | rs7068921 | chr10:124733526 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.04 | 6.23E-5 | Migraine without aura |
| THCA | cis | rs6479874 | 1 | rs7069183 | chr10:52756339 | PRKG1 | chr10:52750945-54055274:+ | -0.2 | -4.65 | 4.3E-6 | Migraine |
| THCA | cis | rs7069346 | 1 | rs7069346 | chr10:124729876 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.08 | 5.3E-5 | Migraine without aura |
| THCA | cis | rs6479891 | 1 | rs7070052 | chr10:64903814 | LOC84989 | chr10:65224989-65226320:+ | -0.27 | -4.43 | 1.15E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs7070052 | chr10:64903814 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -4.69 | 3.58E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs7923609 | 1 | rs7070296 | chr10:65070438 | NRBF2 | chr10:64893007-64914785:+ | -0.29 | -6.8 | 3.13E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |